바이오스펙테이터

Topic 1: Accelerated ADC development via integrated antibody discovery platform

Speaker 1: Dr. Li Chen, Director of Biologics Discovery Dept., GenScript ProBio

Topic 1 Background:

Antibody-drug conjugates, also known as ADC, is a combination of traditional chemotherapy and targeted biological molecule. Recent clinical development brings lots of attention to this particular therapy in oncology filed. In this webinar, we will briefly go over the history and trending of ADC construct, followed by detail discussion of the tools and strategies for antibody discovery, as well as pharmacology assessment of antibody-drug conjugate.

Topic 1 Abstract:

• Brief overview of history and current trending of antibody-drug conjugates.

• Tools and strategies for naked antibody discovery for ADCs

• Early-stage pharmacology evaluation of naked antibody for ADC application

• Pharmacology assessment of ADC candidates

Topic 2: Reaching IND faster with accelerated & high-yielding cell line development

Speaker 2: Dr. Lijuan Xu, Senior Scientist of Process Development dept., GenScript ProBio

Topic 2 Background:

Biopharmaceuticals such as antibodies and recombinant proteins represent rapidly expanding categories of drugs offering new therapeutic applications. Achieving maximum production of these molecules is dependent on many factors such as suitable host cells, expression vectors and culture conditions.

Here, we describe ProBio’s cell line development platform (ProCLD) supporting biopharmaceutical manufacturing with high productivity and purity. An optimized vector pGenHT1.0-UP containing two “TiterUp” elements is utilized for boosting protein production. For bispecific/multispecific antibodies, optimized vector strategies have been used to modulate the relative expression of different polypeptide chains, thereby alleviating the chain mispairing issues. Notably, the turnaround time from transfection to PCB generation has been shortened to 8 weeks with highest titer of 10 g/L.

In summary, we show that ProBio has established superior CLD platform guaranteeing the accelerated and high-yielding cell line development.

Topic 2 Abstract:

• Overview of ProBio’s cell line development (ProCLD)

• Strategies we have established to overcome the challenges in cell line development

• Shortened turnaround timeline to 8 weeks from plasmid to PCB

• Fast-Growing Global Track Record